Pseudoephedrine and Ephedrine For Weight Loss, Asthma, Stuffy Noses.

Pseudoephedrine and Ephedrine

Ephedrine and Pseudoephedrine are two different drugs derived from the Ephedra plant but have similar characteristics. Both are used in OTC medications, both can be used to lose weight, and both can be used to boost athletic performance. They act on the body by imitating the natural effects of the body’s own adrenaline, leading to increased alertness and a boosted metabolism.

Pseudoephedrine and Ephedrine can be confused as they are sold in similar forms such as Primatene and Sudafed. Both are generally marketed in the form of liquid, sprays or tablets. There are some important differences between these two supplements that you should know, especially depending on your reason for using them.

Pseudoephedrine does have significant weight loss abilities, but they are significant less than Ephedrine HCL. Pseudoephedrine is better suited as a decongestant, or to increase alertness. Pseudoephedrine is not a thermogenic, it lacks the calorie burning power that Ephedrine has.

Pseudoephedrine a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It is often used as a nasal or sinus decongestant and can be purchased online or in stores. It has stimulant qualities so it is also used as a alertness promoting agent.   The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate, as mentioned are found in many over the counter medicines, such as Afrinol, Sudafed, Sinutab. They are typically combined with antihistamines, guaifenesin, dextromethorphan, acetaminophen, aspirin or ibuprofen.

Pseudoephedrine is readily reduced into methamphetamine which is the reason Ephedrine and Pseudoephedrine have come under fire and have selling restrictions placed on them. Pseudoephedrine occurs naturally as an alkaloid in ephedra plants, but the majority of pseudoephedrine is derived from yeast fermentation of dextrose in the presence of benzaldehyde. The bulk of pseudoephedrine is produced by India and China.   Without getting too technical, Pseudoephedrine works in this way. While it may have weak agonist activity at a- and ß-adrenergic receptors, the principal mechanism is to cause the release of endogenous norepinephrine (noradrenaline). The noradrenaline is released into the neuronal synapse, where it activates the postsynaptic adrenergic receptors. These adrenergic receptors are located on the muscles lining the walls of blood vessels. When these receptors are activated, the muscles contract, causing the blood vessels to constrict. This  constriction of the blood vessels allows less fluid to leave and enter the nose, throat and sinuses. The result, you can breath better.

Pseudoephedrine is an amphetamine derivative, so it also appears to release dopamine as well, similar to the racemic ephedrine bronchodilator. Pseudoephedrine is also stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant in Afrinol, Sudafed, Sinutab. It reduces nasal congestion commonly associated with colds or allergies. Other beneficial effects may include increasing the drainage of sinus secretions, and opening of obstructed Eustachian tubes.

Pseudoephedrine can be used either as a pill or spray. The pill is recommended over the spray, as sprays can not cause rebound congestion (rhinitis medicamentosa).   Common adverse drug reactions with pseudoephedrine therapy include: CNS stimulation, insomnia, nervousness, excitability, dizziness and anxiety.   Pseudoephedrine should not be by people with; diabetes, cardiovascular disease, severe coronary artery disease, prostatic hypertrophy, hyperthyroidism, severe or uncontrolled hypertension, closed angle glaucoma, or by pregnant women. Patients who are prone to anxiety or panic attacks should use pseudoephedrine with caution, as anxiety and restlessness are common side effects, mostly due to it’s stimulant properties.

If your goal is to lose weight, get relief from asthma symptoms, increase alertness, and get relief from nasal congestions ephedrine is your best choice. To learn more about ephedrine click here.